Garlic & Health
Introduction
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Consumption of garlic may contribute to the prevention of cancer and cardio-vascular
diseases. These diseases are by far the leading causes of death and morbidity in the EU. Increasing garlic consumption and improving the content of the active
compounds, may therefore lower the annual costs of these diseases, which are estimated to be many millions of
Euros.
The European growers of garlic may also benefit from increased garlic
consumption,
especially through growing improved garlic varieties with increased health promoting
capacities.
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Traditional medicine
Garlic has been used for a long time as food with many therapeutic
effects. In spite of this,
few scientific studies have investigated the mechanisms of these effects. There is a crucial lack in studies in which well defined garlic preparations and compounds are
used. The studies so far indicate that the sulphur
containing flavour compounds of the garlic plant are the major component of the health promoting
effects.
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New perspectives
Modern pharmaceutical and genetic techniques may allow an effective study of the underlying mechanisms and the development of improved garlic types.
Therefore, the European Union
has financed a research project on the development of high quality garlic and on the influence of garlic consumption on biomarkers of atherosclerosis and
cancer. The project is financed within the framework of the European research programme ‘Quality of Life and Management of Living Resources’, Key action 1:
Food, Nutrition and Health. The project started in 2000 and has a running time of four
years. The EU funding covers in total some four million Euros.
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15 partners
The EU project (EU-contract: QLK1-CT-1999-0498) is carried out by a consortium of 15 independent research groups from six countries. The consortium consists of universities, research institutes, plant breeding and pharmaceutical companies, each bringing special knowledge and
expertise, such as genetic resources, breeding, cultivation systems, sulphur biochemistry,
or experience in studying pharmaceuticals and their effect on atherosclerosis
and cancer.

Insights
The garlic and health project has two main scientific objectives. The first is to understand and improve the production of active compounds by garlic, through sophisticated breeding techniques. The second aim is to improve the understanding of the role of garlic
in the diet and as a therapy in promoting and sustaining health and preventing cancer and cardiovascular-diseases like atherosclerosis.
Agro economy
The production of garlic (Allium sativum L.) in Europe is concentrated in Mediterranean countries such as Spain, France and
Italy. The market price of European garlic is high, especially in comparison with the garlic grown in China. This price difference could severely threaten the European garlic growers if there was a free market in Europe for
garlic. However, to protect the European garlic growers the European Commission issued a regulation in 1993 that only 12000 tons of Chinese garlic can be imported
annually.
The garlic and health project therefore aims to develop methods, through improved seed technology and genetics, which will enable European garlic growers to meet the internal demand for high quality products and to compete on
an international level.
Improved garlic varieties will be among the concrete products of the project. For this, genetic variation and the genetic background of the production of the active compounds will be studied and new breeding technologies will be developed and applied.
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Targeting health benefits
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The main objective of the health part of the project is to
clarify the role of garlic for the prevention of chronic diseases like
atherosclerosis and cancer. This will be achieved through modern cellular,
molecular and clinical studies in cells, animals and humans. Specific
biomarkers will be identified as indicators for modulation of these
diseases on the cellular and tissue level and in humans. These will serve
as a basis for new intervention studies.
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Project co-ordination
Dr. C. Kik
Overall co-ordination
Dr. R. Kahane
Research leader Plant
Prof. Dr. R. Gebhardt
Research leader Health
EU scientific officers
Dr. L. Breslin
e-mail: Liam.Breslin@cec.eu.int
Dr. R. D'Amario
e-mail: Rosanna.D'Amario@cec.eu.int
European Commission
DG RTD, unit E-2
Square de Meeus 8
B-1050 Brussels
Belgium
More information
Dr. Chris Kik
Plant Research International
Wageningen University & Research Center
P.O. Box 16
6700 AA Wageningen
The Netherlands
tel.: +31 317 47 72 78/ 47 70 01
fax: +31 317 41 80 94
e-mail: chris.kik@wur.nl
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